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Esomeprazole: Drug Description

Esomeprazole is a medication primarily used to treat gastroesophageal reflux disease. The medication is also effective at treating symptoms of some other conditions affecting the stomach, esophagus, and intestines, involving excessive production of stomach acid, including:

  • Erosive esophagitis
  • Zollinger-Ellison syndrome and other pathological hypersecretory conditions
  • H. pylori infections
  • Peptic ulcers associated with NSAIDs.

Esomeprazole is effective at treating heartburn and other symptoms associated with GERD. The medication also improves healing of stomach, esophagus, or intestines damaged by stomach acid.

Esomeprazole is also recommended for people taking NSAIDs for prevention of stomach ulcers.

Mechanism of Action

Esomeprazole is a proton pump inhibitor. Cells that line the stomach use proton pumps to produce stomach acid. Esomeprazole helps treat symptoms of gastroesophageal reflux disease, such as heartburn, by blocking the action of proton pumps, thereby decreasing the amount of acid in your stomach.

Proper Use

Esomeprazole tablets should be taken orally without chewing or crushing them.

Here are the average recommended doses of generic Esomeprazole:

  • The usual recommended dosage of Esomeprazole for treating gastroesophageal reflux disease is 20 mg taken once daily for 4-8 weeks. For severe cases, the recommended dose ranges from 20 mg to 40 mg once a day for 4-8 weeks, followed by Esomeprazole 20 mg taken once a day for relapse prevention.
  • For treating GERD in children aged 1 to 11, the recommended dose is 10 mg a day for up to 8 weeks. For children age 12 to 17 years old, the dose of Esomeprazole varies from 20 mg to 40 mg a day for up to 8 weeks.
  • For people with H. Pylori infection, the recommended dose is 40 mg daily for 10 days. Treatment of H. pylori infection involves taking amoxicillin and clarithromycin in addition to Esomeprazole.
  • When using Esomeprazole to prevent stomach ulcer, the standard dose is 20 mg or 40 mg daily for up to 6 months.
  • People with pathological hypersecretory conditions are usually prescribed 40 mg twice a day.

Your dosage of Esomeprazole may differ from the above average doses. You dose will depend on the condition being treated, other diseases you may have, and other medications you may be taking.

For the medication to work properly, take it as recommended by your doctor. You will find more information on how Esomeprazole should be taken in the Patient Information Leaflet. Make sure you read and understand the information provided in the Leaflet before taking Esomeprazole.