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Estradiol indications

Estradiol is a medication containing a form of estrogen, which is a female sex hormone. This hormone is naturally produced by the ovaries. The body needs estrogen for many processes.

You can use Estradiol for the treating of menopause symptoms that include vaginal dryness, irritation, burning and hot flashes. The medication may also be used for other purposes, for example, for the prevention of osteoporosis in postmenopausal women. The medicament can also be used for the replacement of estrogen in female patients with ovarian failure or any other disorders that cause a deficit of natural estrogen in the body.

Estradiol may also be used as s part of cancer treatment in both male and female patients.

The medication can’t be used for preventing dementia, heart disease or stroke, because it may bring you at higher risks of developing these disorders.

Estradiol contraindications and precautions

You cannot use Estradiol if you have an allergy to estradiol, unchecked abnormal vaginal bleeding, any type of hormone-dependent cancer, liver disease, a history of blood clot, a recent heart attack, food or medicine allergies.

Having certain conditions means a patient may need a dosage adjustment or should take the medication carefully. In case with Estradiol these conditions include family history of blood clots; gallbladder disease; kidney disease; underactive thyroid; lupus; heart disease; migraines; endometriosis; a history of jaundice; low levels of calcium in the blood; uterus removed; porphyria; any seizure disorder; asthma.

Estradiol during pregnancy and breast-feeding

The medication has FDA pregnancy category X, it means it is extremely harmful for a fetus (may cause severe birth defects). Pregnant women should never use this medicine.

Estradiol was also found as harmful for a nursing baby. The med is able to pass into breast milk. Moreover, it may reduce lactation. So, breast-feeding women should resist using this med either.

Estradiol administration

It’s essential to take the medication strictly as prescribed to get benefits from the treatment. Violating dosage or schedule of drug taking may result in developing of negative effects that may cause serious harm to your health.

Never exceed your dosage. In case of overdose you may have vomiting or vaginal bleeding. Long-term treatment with Estradiol increases the risk of ovarian cancer, breast cancer or uterine cancer.

After you use Estradiol, read administration paragraph attentively. The medicine is to be taken by mouth with a glass of water.

When you are using Estradiol, do not smoke, as smoking increases the risk of heart attack, blood clotting and stroke.

Estradiol side effects

Before you use Estradiol, you should know that your body may not accept the new medication. If it happens so, you will have the signs of an allergic reaction in form of hives, swollen parts of your face andor body andor difficulty breathing. Get medical help immediately after developing any of these symptoms.

Please, stop the treatment and get medical attendance asap if you have any of severe side effects: a lump in the breast; unusual vaginal bleeding (esp. in post-menopausal women); sudden severe headache; chest pain; redness, swelling, pain, warmth in one/both legs; heavy feeling; tenderness, pain or swelling in the stomach; stabbing chest pain; pain that spreads to th у shoulder or arm; sweating; rapid breathing; general ill feeling; nausea; problems with vision; confusion; balance problems; changes and disturbances of hearing; sudden numbness or weakness; feeling like you might pass out; sudden cough; jaundice; increased thirst; vomiting; feeling tired; muscle weakness; wheezing; loss of appetite; fast heart rate.

Less serious Estradiol side effects include darkening of facial skin; stomach cramps; changes in menstrual periods; vaginal itching; breast pain or tenderness; mild nausea; break-through bleeding; loss of scalp hair; bloating; freckles in the face; vomiting.

Estradiol drug interactions

You should know that taking several medications at the same time may cause negative effects due to substances mixing. That’s why, before you use Estradiol, keep in mind that this medicament may badly interact with some other medicines, supplements and herbal products including cimetidine (Tagamet); St. John’s wort; carbamazepine (Carbatrol, Tegretol); ritonavir (Norvir); phenobarbital (Luminal, Solfoton); antibiotics like erythromycin (Erythrocin, Ery-Tab, E-Mycin, E.E.S.) or clarithromycin (Biaxin); rifampin (Rifadin, Rimactane, Rifater, Rifamate,); phenytoin (Dilantin); antifungal medicaments like as ketoconazole (Ketozole, Nizoral, Extina, Xolegal); blood thinners like warfarin (Coumadin).


Estradiol, as the majority of meds, is to be stored in a cool place that is protected from direct light and moisture. Keep the medicine out of reach of pets and children, never use expired medicaments.