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Metformin: Drug Description

Metformin is a medication approved for the treatment of type 2 diabetes. Type 2 diabetes, also sometimes called noninsulin-dependent diabetes, is the most common type of diabetes. This condition involves insulin resistance, which means that the body does not respond to insulin as well as it should. As a result, sugar is not removed from the blood properly.

The medication also helps reduce the chances of developing diabetes complications, such as diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, and heart disease.

Metformin is intended to be used in combination with diet, exercise, and other lifestyle changes to keep blood sugar levels under control. Off-label uses of Metformin include the treatment of gestational diabetes, polycystic ovarian syndrome, and HIV lipodystrophy. How does it work?

Metformin decreases the amount of sugar which your body absorbs by decreasing the amount of glucose produced by the liver. Because of this effect, metformin helps your body respond to insulin and decrease blood sugar levels.

Unlike many other diabetes medications, Metformin has several effects in the body. The medication helps lower blood sugar levels in several ways:

  • It decreases the amount of glucose that liver produces.
  • Metformin decreases the amount of sugar that your body absorbs from food.
  • The medication improves the sensitivity of insulin receptors, making the body more responsive to insulin.
Because Metformin does not cause increase the amount of insulin produced by the pancreas, it is less likely to cause hypoglycemia.

In addition to controlling blood sugar, there are several other Metformin benefits, including:

  • Lowering LDL cholesterol
  • Raising HDL cholesterol
  • Helping lose weight
  • Improving fertility in women who have polycystic ovarian syndrome
  • Decreasing chances of miscarriages in women with polycystic ovarian syndrome

How Metformin should be used?

Metformin tablets should be taken orally with meals once or twice daily.

The dosage of Metformin depends on several factors, among which are whether you are taking insulin or not, and how well your diabetes responds to Metformin. The recommended starting Metformin dosage is 500 mg taken twice daily or 850 mg once daily. The dose may be gradually increased if necessary. The maximum daily dosage is 2550 mg.

The recommended dosage of Metformin for people taking insulin is 500 mg taken once daily.